Moderator: zizzia
Modern human newborns have only 25 per cent of adult brain capacity, resulting in an extended period of helplessness. The many neurological pathways to the rapidly growing brain must be organized and coordinated during a prolonged period of dependency on and stimulation by adults; lacking this close external bond in the early years of life, development of the modern brain remains incomplete.
In development, timing is of the utmost importance, and the timing of developmental processes often changes as organisms evolve. In human evolution, developmental retardation, or neoteny, has been proposed as a possible mechanism that contributed to the rise of many human-specific features, including an increase in brain size and the emergence of human-specific cognitive traits.
We show that the brain transcriptome is dramatically remodeled during postnatal development and that developmental changes in the human brain are indeed delayed relative to other primates. This delay is not uniform across the human transcriptome but affects a specific subset of genes that play a potential role in neural development.